SCIENCE - Less toxic metabolites, more chemical product

By preventing the build-up of toxic metabolites in engineered microbes, a dynamic regulatory system can help boost production of an advanced biofuel, a therapeutic drug, or other valuable chemical products. The system has already been used to double the production in E. coli of amorphadiene, a precursor to the premier antimalarial drug artemisinin ...

http://www.sciencedaily.com/releases/2013/10/131029133554.ht